In 1988 Ben van Berkel and Caroline Bos set up an architectural practice in Amsterdam: The Van Berkel & Bos Architectuurbureau, extending their joint theoretical and writing projects to the practice of architecture.
In 1998 they established a new firm: UNStudio (United Net). UNStudio presents itself as a network of specialists in architecture, urban development and infrastructure. Current projects are the restructuring of the station area of Arnhem, the mixed-use Raffles City in Hangzhou, a masterplan for Basauri, a dance theatre for St. Petersburg and the design and restructuring of the Harbor Ponte Parodi in Genoa. With UNStudio they realized amongst others the Mercedes-Benz Museum in Stuttgart, a façade and interior renovation for the Galleria Department store in Seoul and a private villa up-state New York.
Ben van Berkel and Caroline Bos have lectured and taught at many architectural schools around the world. Ben van Berkel is currently Professor Conceptual Design at the Staedelschule in Frankfurt am Main.